Production and Biological Activity of Secalonic Acid D

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منابع مشابه

Production and biological activity of secalonic Acid d.

Twenty isolates of Penicillium oxalicum produced secalonic acid as their major secondary metabolite. Fermentation conditions were determined for toxin production in grain and liquid media. The 50% lethal dose value for mice ranged from 26.5 to 51.7 mg/kg dependent on animal strain and sex, males being more susceptible than females. Secalonic acid was nontoxic and nonteratogenic to the chicken e...

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Effect of Amino Acid Substitutions on Biological Activity of Antimicrobial Peptide: Design, Recombinant Production, and Biological Activity

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15 صفحه اول

Enhancement of influenza virus infections by secalonic acid D.

Secalonic acid D (SAD), a hepatotoxic, teratogenic, and slightly mutagenic metabolite of Penicillium oxalicum has been identified as a natural contaminant of grain dust. Secalonic acid D was administered intraperitoneally to male ICR mice that were exposed to influenza virus aerosols 5 days earlier. The mortality rate was significantly higher (p less than 0.001) in mice subjected to both influe...

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ژورنال

عنوان ژورنال: Applied and Environmental Microbiology

سال: 1980

ISSN: 0099-2240,1098-5336

DOI: 10.1128/aem.39.2.285-287.1980